VEGFB Knockout Mice

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SKU: MS-VEGFB Category:

Product Description

VEGFB Knockout Mice

This Vascular Endothelial Growth Factor B (VEGFB) knockout mouse model was created by targeted disruption of VEGFB using programed nuclease. VEGFB is a member of the VEGF/Platelet-Derived Growth Factor (PDGF) family which regulates the formation of blood vessels and is involved in endothelial cell physiology. VEGFB is alternately spliced into two distinct isoforms, VEGF-B167 and VEGF-B186. VEGFB is a ligand for Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) and Neuropilin-1 (NRP-1). Mutations are confirmed by PCR genotyping and Sanger sequencing. Heterozygous mice are in breeding now and homozygous mice will be available soon. This VEGFB KO mouse model will be useful for diabetes and metabolic homeostasis research.

STRAIN DETAILS
Strain Background: C57BL6/SJL
Chromosome: 19
Gene: Vegfb
Protein: Vascular Endothelial Growth Factor B
Synonyms: VEGF-B, VEGF-Related Factor, VRF, VEGFL
Genomic Target: Exon 3
Mutation: Large deletions

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

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