tPA Knockout Mice
This Tissue Plasminogen Activator (tPA) knockout mouse model was created by targeted disruption of Plat using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. Complete absence of tPA expression in homozygous mice has been confirmed by Western Blot of brain tissue lysates. Loss of tPA activity has been determined by ELISA. Homozygous mice are available immediately. This tPA KO mouse model will be useful for cardiovascular and neurological studies.
Strain background: C57B6SJL
Protein: Tissue Plasminogen Activator
Targeted Exon: Exon 4
Mutation: 16 bp deletion
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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