tPA Knockout Mice


SKU: MS-TPA Category:

Product Description

tPA Knockout Mice

This Tissue Plasminogen Activator (tPA) knockout mouse model was created by targeted disruption of Plat using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. Complete absence of tPA expression in homozygous mice has been confirmed by Western Blot of brain tissue lysates. Loss of tPA activity has been determined by ELISA. Homozygous mice are available immediately. This tPA KO mouse model will be useful for cardiovascular and neurological studies.

Strain Background: C57BL6/SJL
Chromosome: 8
Gene: Plat
Protein: Tissue Plasminogen Activator
Synonyms: tPA
Genomic Target: Exon 4
Mutation: 16 base pair deletion

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

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