TPA Knockin Mice

$500

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SKU: MS-TPA-S510 Category:

Product Description

TPA Knockin Mice

This Tissue Plasminogen Activator (tPA) knockin mouse model was created by targeted substitution of active-site serine at position 510 (or 478 in mature peptide) using programed nuclease. This serine residue is critical for plasminogen activation and formation of stable complexes between tPA and PAI-1. Homozygous mice will be available in September 2020.

STRAIN DETAILS
Strain Background: C57BL/6J
Chromosome: 8
Gene: Plat

Gene ID: 18791
Protein: Tissue Plasminogen Activator

Synonyms: tPA
Genomic Target: Exon 14
Mutation: Ser510 > Ala

 

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