TPA Knockin Mice
This Tissue Plasminogen Activator (tPA) knockin mouse model was created by targeted substitution of active-site serine at position 510 (or 478 in mature peptide) using programed nuclease. This serine residue is critical for plasminogen activation and formation of stable complexes between tPA and PAI-1. Homozygous mice will be available in September 2020.
Strain Background: C57BL/6J
Gene ID: 18791
Protein: Tissue Plasminogen Activator
Genomic Target: Exon 14
Mutation: Ser510 > Ala
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