Prekallikrein Knockout Mice

$400

Clear
SKU: MS-PK Category:

Product Description

Prekallikrein Knockout Mice

This prekallikrein knockout mouse model was created by targeted disruption of Klkb1 using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. The complete absence of plasma kallikrein B protein in the plasma of homozygous mice is confirmed by Western Blot. Prekallikrein is the single chain gamma globulin glycoprotein zymogen precursor of the plasma serine protease kallikrein. This mouse has a greatly extended clotting time because of this deficiency in the early phase of the intrinsic pathway of the clotting cascade. Kinin formation and fibrinolysis may be impacted in addition to the contact activation system.

STRAIN DETAILS
Strain Background: C57BL6/SJL
Chromosome: 8
Gene: Klkb1
Protein: Plasma kallikrein B
Synonyms: Prekallikrein
Genomic Target: Exon 1
Mutation: 5 base pair deletion
Phenotype: Absence of Klkb1 protein expression, extended clotting time

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

You may also like…