PAI-1 Knockout Mice


SKU: MS-PAI Category:

Product Description

PAI-1 Knockout Mice

This Plasminogen Activator Inhibitor-1 (PAI-1) knockout mouse model was created by targeted disruption of Serpine1 using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. Homozygotes display baseline active PAI-1 level after endotoxin injection. This PAI-1 KO mouse model will be useful for studying fibrinolysis, aging, diabetes and cardiovascular diseases [1-3].

Strain Background: C57BL6/SJL, backcrossed to C57BL/6J
Chromosome: 5
Gene: Serpine1
Protein: Plasminogen Activator Inhibitor-1
Synonyms: PAI-1
Genomic Target: Exon 2
Mutation: 4 base pair deletion
Phenotype: Baseline active PAI-1 level upon endotoxin stimulation

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

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We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

Table 1 Typical PAI-1 activity in plasma after LPS injection (1.25 mg/kg)


  1. Yarmolinsky J, Bordin Barbieri N, Weinmann T, Ziegelmann PK, Duncan BB, Schmidt MI. Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies. Sci Rep. 2016. 6(1):17714.
  2. Song C, Burgess S, Eicher JD, O’Donnell CJ, Johnson AD. Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. J Am Heart Assoc. 2017. 6(6):e004918.
  3. Khan SS, Shah SJ, Klyachko E, Baldridge AS, Eren M, Place AT, et al. A null mutation in SERPINE1 protects against biological aging in humans. Sci Adv. 2017. 3(11):eaao1617.

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