PAI-1 Knockout Mice
This Plasminogen Activator Inhibitor-1 (PAI-1) knockout mouse model was created by targeted disruption of Serpine1 using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. Homozygotes display baseline active PAI-1 level after endotoxin injection. This PAI-1 KO mouse model will be useful for studying fibrinolysis, aging, diabetes and cardiovascular diseases [1-3].
Strain Background: C57BL6/SJL, backcrossed to C57BL/6J
Protein: Plasminogen Activator Inhibitor-1
Genomic Target: Exon 2
Mutation: 4 base pair deletion
Phenotype: Baseline active PAI-1 level upon endotoxin stimulation
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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Table 1 Typical PAI-1 activity in plasma after LPS injection (1.25 mg/kg)
- Yarmolinsky J, Bordin Barbieri N, Weinmann T, Ziegelmann PK, Duncan BB, Schmidt MI. Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies. Sci Rep. 2016. 6(1):17714.
- Song C, Burgess S, Eicher JD, O’Donnell CJ, Johnson AD. Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. J Am Heart Assoc. 2017. 6(6):e004918.
- Khan SS, Shah SJ, Klyachko E, Baldridge AS, Eren M, Place AT, et al. A null mutation in SERPINE1 protects against biological aging in humans. Sci Adv. 2017. 3(11):eaao1617.