PAI-1 Knockin Mice
This Plasminogen Activator Inhibitor-1 (PAI-1) knockin mouse model was created by targeted substitution of critical amino acids using programed nuclease. A single amino acid point mutation results in PAI-1 with reduced binding to the serum protein vitronectin. These vitronectin binding deficient mice are in breeding now and homozygous mice will be available soon.
Strain Background: C57BL6/SJL
Protein: Plasminogen Activator Inhibitor-1
Genomic Target: Exon 2
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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