Mouse PAI-1 (wild type active fraction)


SKU: MPAI Categories: ,

Product Description

Recombinant mouse PAI-1 is the ideal choice for studies involving this animal model of fibrinolysis and cancer studies. The active fraction typically contains 30-70percent active PAI-1.

Gene ID: 18787
Swiss-Prot/UniProt ID: P22777

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1. Vayalil PK, Olman M, Murphy-ullrich JE et-al. Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen. Am. J. Physiol. Lung Cell Mol. Physiol. 2005;289 (6): L937-45. doi:10.1152/ajplung.00150.2005Pubmed citation

2. Allen GB, Leclair T, Cloutier M et-al. The response to recruitment worsens with progression of lung injury and fibrin accumulation in a mouse model of acid aspiration. Am. J. Physiol. Lung Cell Mol. Physiol. 2007;292 (6): L1580-9. doi:10.1152/ajplung.00483.2006Pubmed citation

3. Norris EH, Strickland S. Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system. Proc. Natl. Acad. Sci. U.S.A. 2007;104 (33): 13473-8. doi:10.1073/pnas.0705848104Free text at pubmedPubmed citation

4. Cooper JM, Rastogi A, Krizo JA, Mintz EM, Prosser RA. Urokinase-type plasminogen activator modulates mammalian circadian clock phase regulation in tissue-type plasminogen activator knockout mice. Eur J Neurosci. 2016; Link to article

5. Luo M, Ji Y, Luo Y, Li R, Fay WP, Wu J. Plasminogen activator inhibitor-1 regulates the vascular expression of vitronectin. J Thromb Haemost. 2017; Link to article

6. Praetner M, Zuchtriegel G, Holzer M, et al. Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion. Arterioscler Thromb Vasc Biol. 2018;38(4):829-842. Link to article