Mouse PAI-1 (stable mutant)


SKU: MPAI-I91L Categories: ,

Product Description

Using information obtained from the studies which produced stabilized human PAI-1 (CPAI) we have available a form of mouse PAI-1 that has a single conservative mutation (Isoleucine 91 to Leucine).

Gene ID: 18787
Swiss-Prot/UniProt ID: P22777

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1. Arndt PG, Young SK, Worthen GS. Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. J. Immunol. 2005;175 (6): 4049-59. J. Immunol. (link)Pubmed citation

2. Vayalil PK, Olman M, Murphy-ullrich JE et-al. Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen. Am. J. Physiol. Lung Cell Mol. Physiol. 2005;289 (6): L937-45. doi:10.1152/ajplung.00150.2005Pubmed citation

3. Arndt PG, Young SK, Poch KR et-al. Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways. J. Immunol. 2006;177 (10): 7233-41. J. Immunol. (link)Pubmed citation

4. Sashindranath M, Sales E, Daglas M et-al. The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain. 2012;135 (Pt): 3251-64. doi:10.1093/brain/aws178Free text at pubmedPubmed citation