Monoclonal antibody to human 85 kDa light chain of LRP. Cross-reacts with rabbit and mouse LRP. Stimulates cellular-mediated uptake of alpha 2 macroglobulin trypsin complex by LRP1. Use WI-38 fibroblast as positive control and human umbilical vein endothelial cells (HUVEC) as negative control. Low density lipoprotein receptor-related protein 1 (LRP1, LRP-1), also known as alpha-2-macroglobulin receptor (A2MR), cluster of differentiation 91 (CD91), and apolipoprotein E receptor (APOER), is a transmembrane receptor protein that is expressed as a non-covalently associated 515 kDa alpha chain and 85 kDa beta chain.
Purified by immobilized Protein A. IgG2b kappa class.
Gene ID: 4035
Swiss-Prot/UniProt ID: Q07954
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1. Jehle AW, Gardai SJ, Li S et-al. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J. Cell Biol. 2006;174 (4): 547-56. doi:10.1083/jcb.200601030 – Free text at pubmed – Pubmed citation
2. Lambert MP, Wang Y, Bdeir KH et-al. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. Blood. 2009;114 (11): 2290-8. doi:10.1182/blood-2009-04-216473 – Free text at pubmed – Pubmed citation
3. Shi G, Field DJ, Long X et-al. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Blood. 2013;121 (21): 4417-27. doi:10.1182/blood-2012-09-454710 – Free text at pubmed – Pubmed citation
4. Bavelloni A, Piazzi M, Raffini M, Faenza I, Blalock WL. Prohibitin 2: At a communications crossroads. IUBMB Life. 2015;67(4):239-54. Link to article