Kininogen Knockout Mice


SKU: MS-KNG Category:

Product Description

Kininogen Knockout Mice

This Kininogen (KNG1) knockout mouse model was created by targeted disruption of KNG1 using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. The complete absence of kininogen protein in the plasma of homozygous mice is confirmed by Western Blot. High molecular weight kininogen (HMWK) is a cofactor for activation of prekallikrein, Factor XII, and Factor XI. This mouse has an extended clotting time because of this deficiency in a critical component of the intrinsic pathway of the clotting cascade. Kininogen is the precursor of the vasodilator peptide bradykinin and genetic deficiency may also impact blood pressure, inflammation, and pain responses. This KNG1 KO mouse model will be useful for cardiovascular studies including intrinsic/contact pathway coagulation and hypertension research. These kininogen deficient mice are in breeding now and homozygous mice will be available soon.

Strain Background: C57BL/6
Chromosome: 16
Gene: KNG1
Protein: Kininogen-1
Synonyms: KNG, Fitzgerald Factor, Alpha-2-thiol Proteinase Inhibitor
Genomic Target: Exon 4
Mutation: 2 base pair deletion

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

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