Inhibitory mouse monoclonal to human PAI-1

Inhibitory mouse monoclonal to human PAI-1 clone 8H9D4

$995 – $8,950

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SKU: MA-8H9D4 Categories: ,

Product Description

Inhibitory mouse monoclonal to human PAI-1 clone 8H9D4

Inhibitory monoclonal antibody to human and porcine PAI-1. Does not cross-react with mouse or rat. It binds to the axis connecting Arg300, Gln303 and Arg305 interfering with the final step of covalent complex formation. MA-8H9D4 shifts the reaction to the substrate pathway without decreasing the rate-limiting constant for reactive center loop insertion by tPA. IgG fraction purified by immobilized Protein A. Clone 8H9D4, isotype IgG1.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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1. Kubala MH, Punj V, Placencio-hickok VR, et al. Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer. Cell Rep. 2018;25(8):2177-2191.e7. Link to article

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