Inhibitory mouse monoclonal to human PAI-1 clone 8H9D4
Inhibitory monoclonal antibody to human and porcine PAI-1. Does not cross-react with mouse or rat. It binds to the axis connecting Arg300, Gln303 and Arg305 interfering with the final step of covalent complex formation. MA-8H9D4 shifts the reaction to the substrate pathway without decreasing the rate-limiting constant for reactive center loop insertion by tPA. IgG fraction purified by immobilized Protein A. Clone 8H9D4, isotype IgG1.