Inhibitory mouse monoclonal to human 515 kDa LRP

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Inhibitory mouse monoclonal to human 515 kDa LRP

Monoclonal antibody to human 515 kDa heavy chain of LRP. Useful marker for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD91). Blocks cellular-mediated uptake of alpha 2 macroglobulin trypsin complex by LRP1. Use WI-38 fibroblast as positive control and human umbilical vein endothelial cells (HUVEC) as negative control. Low density lipoprotein receptor-related protein 1 (LRP1, LRP-1), also known as alpha-2-macroglobulin receptor (A2MR), cluster of differentiation 91 (CD91), and apolipoprotein E receptor (APOER), is a transmembrane receptor protein that is expressed as a non-covalently associated 515 kDa alpha chain and 85 kDa beta chain. Purified by immobilized Protein A. IgG1kappa class.

Gene ID: 4035
Swiss-Prot/UniProt ID: Q07954

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1. Elvington M, Liszewski MK, Bertram P, Kulkarni HS, Atkinson JP. A C3(H20) recycling pathway is a component of the intracellular complement system. J Clin Invest. 2017;127(3):970-981. Link to article

3. Brooks MB, Turk JR, Guerrero A, et al. Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability. PLoS ONE. 2017;12(1):e0169976. Link to article

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