Inhibitory mouse monoclonal to human 515 kDa LRP
Monoclonal antibody to human 515 kDa heavy chain of LRP. Useful marker for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD91). Blocks cellular-mediated uptake of alpha 2 macroglobulin trypsin complex by LRP1. Use WI-38 fibroblast as positive control and human umbilical vein endothelial cells (HUVEC) as negative control. Low density lipoprotein receptor-related protein 1 (LRP1, LRP-1), also known as alpha-2-macroglobulin receptor (A2MR), cluster of differentiation 91 (CD91), and apolipoprotein E receptor (APOER), is a transmembrane receptor protein that is expressed as a non-covalently associated 515 kDa alpha chain and 85 kDa beta chain. Purified by immobilized Protein A. IgG1kappa class.