Human Protein C Receptor, C-terminal 6x His tag
Endothelial Protein C Receptor (EPCR) is a type I transmembrane glycoprotein in the CD1/MHC family expressed in endothelial cells. Binding of Protein C to EPCR enhances activation by the thrombin-thrombomodulin complex. Bound APC cleaves Protease-Activated Receptor 1 (PAR1) leading to up-regulation of Protein C-induced genes. The glycosylated extracellular domain (Ser18-Ser210) is recombinantly produced in mammalian cell culture and purified then sterile filtered and lyophilized. Contains a 6X-Histidine tag at C terminus for purification. The protein purity is determined by SDS-PAGE. Add PBS to greater than 0.1 mg/ml, aliquot and freeze unused portion.