Hemophilia B Mice


SKU: MS-FIX Category:

Product Description

Hemophilia B Mice

This hemophilia B mouse model was created by targeted disruption of Factor IX (F9) using programed nuclease. Mutations are confirmed by PCR genotyping, Sanger sequencing, and RT-PCR. Male hemizygotes display severe hemophilia B phenotype with prolonged blood clotting time and exhibit death after tail clipping without cauterizing. This hemophilia B mouse model will be useful for studying gene therapy methods.

Strain Background: C57BL6/SJL
Chromosome: X
Gene: F9
Protein: Coagulation Factor IX
Synonyms: FIX, Christmas Factor
Genomic Target: Exon 1
Mutation: 2 base pair deletion
Phenotype: Prolonged clotting time (aPTT), tail clipping induced mortality

Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

We also provide custom Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report. Click here to learn more about all the various knockout and knockin mouse models we offer.

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