Haptoglobin, Phenotype 2-2, Human Plasma
Haptoglobin is an acute phase plasma glycoprotein that binds free hemoglobin. Hemoglobin-haptoglobin complexes are removed by the macrophage CD163 receptor. Humans possess two major haptoglobin alleles that are inherited co-dominantly resulting in three possible phenotypes. Hp 2-2 is the least effective in binding free hemoglobin and circulates as a range of multimers in serum. Purified from single donors screened by SDS-PAGE and western blot for the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.