C1 Inhibitor Knockout Mice
Plasma protease C1 inhibitor, also known as C1 esterase inhibitor, C1-inhibiting factor, C1-INH, and C1IN, is a product of the SERPING1 gene. It is a serine protease inhibitor (serpin) that is involved in the regulation of the contact and complement systems. Heterozygous defect or deficiency of this protein is responsible for hereditary angioedema (HAE). C1 inhibitor may also prove to be an ideal therapeutic target for investigating additional diseases such as hemorrhagic shock, septic shock, transplant rejection, reperfusion injury, and other inflammatory disorders.
Molecular Innovations has developed a knockout mouse strain that has the C1 inhibitor gene removed by targeted gene excision using programed nuclease. Homozygous mice completely lacking C1 inhibitor protein expression are available, as well as heterozygous mice to model human HAE.
Strain Background: C57BL6/SJL
Protein: Serine (or cysteine) peptidase inhibitor, clade G, member 1
Synonyms: C1INH, C1 inhibitor, C1nh
Genomic Target: Intron 1, Exon 8
Mutation: 9244 base pair deletion
Phenotype: Absence of C1Inh protein expression, increased vascular permeability
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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