Active mouse tPA, recombinant


SKU: MTPA Categories: ,

Product Description

Active mouse tPA, recombinant

Recombinantly produced in insect cells. >95percent active.

Gene ID: 18791
Swiss-Prot/UniProt ID: P11214

View sample datasheet
View sample certificate of analysis
View material safety data sheet
Ask a question about this product

Additional Information



Molecular Weight

Extinction Coefficient



Shipping Conditions





Sample Size

Sample Concentration

Sample Volume

Gene Name

Gene ID

UniProt ID

1. Roelofs JJ, Rouschop KM, Leemans JC et-al. Tissue-type plasminogen activator modulates inflammatory responses and renal function in ischemia reperfusion injury. J. Am. Soc. Nephrol. 2006;17 (1): 131-40. doi:10.1681/ASN.2005010089Pubmed citation

2. Hu K, Yang J, Tanaka S et-al. Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J. Biol. Chem. 2006;281 (4): 2120-7. doi:10.1074/jbc.M504988200Pubmed citation

3. Merchan JR, Tang J, Hu G et-al. Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model. J. Natl. Cancer Inst. 2006;98 (11): 756-64. doi:10.1093/jnci/djj208Pubmed citation

4. Polavarapu R, Gongora MC, Yi H et-al. Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood. 2007;109 (8): 3270-8. doi:10.1182/blood-2006-08-043125Free text at pubmedPubmed citation

5. Zhang X, Polavarapu R, She H et-al. Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation. Am. J. Pathol. 2007;171 (4): 1281-90. doi:10.2353/ajpath.2007.070472Free text at pubmedPubmed citation

6. An J, Zhang C, Polavarapu R et-al. Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood. 2008;112 (7): 2787-94. doi:10.1182/blood-2008-02-141630Free text at pubmedPubmed citation

7. Lund IK, Jögi A, Rønø B et-al. Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo. J. Biol. Chem. 2008;283 (47): 32506-15. doi:10.1074/jbc.M801924200Pubmed citation

8. Roelofs JJ, Rouschop KM, Teske GJ et-al. Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection. Nephrol. Dial. Transplant. 2009;24 (3): 801-8. doi:10.1093/ndt/gfn562Pubmed citation

9. Ilkovitch D, Lopez DM. Urokinase-mediated recruitment of myeloid-derived suppressor cells and their suppressive mechanisms are blocked by MUC1/sec. Blood. 2009;113 (19): 4729-39. doi:10.1182/blood-2008-08-176438Free text at pubmedPubmed citation

10. Roussel BD, Macrez R, Jullienne A et-al. Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact. Brain. 2009;132 (Pt): 2219-30. doi:10.1093/brain/awp162Free text at pubmedPubmed citation

11. Wu F, Wu J, Nicholson AD et-al. Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain. J. Neurosci. 2012;32 (29): 9848-58. doi:10.1523/JNEUROSCI.1241-12.2012Free text at pubmedPubmed citation

12. Li J, Yu L, Gu X et-al. Tissue plasminogen activator regulates Purkinje neuron development and survival. Proc. Natl. Acad. Sci. U.S.A. 2013;110 (26): E2410-9. doi:10.1073/pnas.1305010110Free text at pubmedPubmed citation

13. Sanderson-smith ML, Zhang Y, Ly D et-al. A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection. PLoS Pathog. 2013;9 (7): e1003469. doi:10.1371/journal.ppat.1003469Free text at pubmedPubmed citation

14. Valapala M, Maji S, Borejdo J et-al. Cell Surface Translocation of Annexin A2 Facilitates Glutamate-induced Extracellular Proteolysis. J. Biol. Chem. 2014;289 (23): 15915-15926. doi:10.1074/jbc.M113.511550Free text at pubmedPubmed citation

15. Chen, Chia-Chien, Philip Chu, and Joshua C. Brumberg. ‘Experience-Dependent Regulation Of Tissue-Type Plasminogen Activator In The Mouse Barrel Cortex’. Neuroscience Letters (2015): n. pag. Web. 5 June 2015. Link to article

16. Wu F, Torre E, Cuellar-giraldo D, et al. Tissue-type plasminogen activator triggers the synaptic vesicle cycle in cerebral cortical neurons. J Cereb Blood Flow Metab. 2015. Link to article

17. Lewandowski SA, Nilsson I, Fredriksson L, et al. Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration. Acta Neuropathol. 2016;131(3):453-64.

18. Su EJ, Fredriksson L, Geyer M, et al. Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med. 2008;14(7):731-7. Link to article

19. Jeanneret V, Wu F, Merino P, et al. Tissue-type Plasminogen Activator (tPA) Modulates the Postsynaptic Response of Cerebral Cortical Neurons to the Presynaptic Release of Glutamate. Front Mol Neurosci. 2016;9:121. Link to article.

20. Andersen LM, Wind T, Hansen HD, Andreasen PA. A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue. Biochem J. 2008;412(3):447-57. Link to article

21. Rzeczycki, P. The Role of Macrophages in the Sequestration of Drug and Formation of Insoluble Drug Aggregates. Link to article

22. García-vázquez FA, Soriano-Úbeda C, Laguna-barraza R, et al. Tissue plasminogen activator (tPA) of paternal origin is necessary for the success of invitro but not of invivo fertilisation in the mouse. Reprod Fertil Dev. 2018; Link to article

23. Diaz A, Jeanneret V, Merino P, Mccann P, Yepes M. Tissue-type plasminogen activator regulates p35-mediated Cdk5 activation in the postsynaptic terminal. J Cell Sci. 2019;132(5). Link to article