Japanese Black Rice Vinegar Kurozu May Have Antithrombotic Effects

Japanese believe that it contains rich amino acids and natural products, and has many health benefits:

  • Stabilizes blood pressure
  • Improves blood circulation
  • Promotes digestion and reduces constipation

Kurozu is also considered a healthy drink. Here is a recipe for home-made Kurozu drink:

  • Milk: 150 mL
  • Kurozu: 20-30 mL
  • Honey: some

Kurozu has been reported to have anti-cancer activity in vivo in rats and in vitro in human cancer cells. A research study published in September of 2018 reported that Kurozu and the solid sediment showed antithrombotic activity in mice. In this study, researchers fed mice a Kurozu-rich diet for four weeks, then the mice were injected with lipopolysaccharide (LPS), which is a bacterial toxin that induces a strong response in mammalian immune system. Researchers then evaluated the total and active levels of an inflammation biomarker – plasminogen activator inhibitor-1 (PAI-1) – using ELISA kits (Molecular Innovations, Novi, MI, USA).

PAI-1 plays an important role in fibrinolysis and elevated PAI-1 suppresses the normal fibrinolytic system.  Interestingly, in this study, Kurozu diet significantly blocked LPS-induced increases in PAI-1 levels in mice. In clinic, elevated levels of PAI-1 are observed in various prothrombotic states including obesity, diabetes, insulin resistance and hypertension. The authors indicated that Kurozu and solid sediment may serve as a food supplement for people with obesity, diabetes and hypertension.

Further reading:

Naoki Ohkura; Fumiko Kihara-Negishi; Akira Fujii; et al. Effects of Fermented Rice Vinegar Kurozu and Its Sediment on Inflammation-Induced Plasminogen Activator Inhibitor 1 (PAI-1) Increase. Food and Nutrition Sciences. Sep 2018  doi: 10.4236/fns.2018.93018

Molecular Innovations Provides These Products Available Immediately:

%d bloggers like this: