Product Datasheet

 
Product Description
 
Product: Kininogen, Single Chain HMW, Human Plasma
Catalog Number: HK-HMW
Product Page: https://www.mol-innov.com/products/IHUKNGSCHMW1MG
Description: HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a nonenzymatic cofactor of the contact activation system of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogen links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor alpha-Xlla. Kininogen also forms a complex with Factor XI and accelerates its activation to XIa by alpha-Xlla. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease. >95percent pure by SDS-PAGE and >95percent single chain. Prepared from plasma found negative by FDA accepted methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).
Recommended Storage: SAMPLE
Minimum Shelf Life: 289.75
Source: 2.0 mg/ml
Molecular Weight: Proteins
Extinction Coefficient: 120,000
Antigen: -70 C
Target: Frozen liquid
Target Molecular Weight: KININOGEN
Host: 1292
Clonality: 5
Isotype: Human plasma
Clone: s
Applications: Dry ice
Cross-reactivity: 3 years from delivery
 
Sample Characteristics
 
Lot Number: HK-HMW-IHUKNGSCHMW5MG
Aliquot: 1 x Human Kininogen Single Chain Purified High Molecular Weight 5mg
Concentration: 305
Volume: 1360
Titer: 0.004M Sodium Acetate; 0.15M NaCl; pH 5.3
Buffer: SAMPLE
Form: 1.0 mg
Preservative: 0.5 ml
 
Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet.
 
For in vitro laboratory use only
 
Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com