Product Datasheet
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| Product Description |
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| Product: |
Human PAI-1 (stable vitronectin binding negative mutant) |
| Catalog Number: |
CPAI-QR |
| Product Page: |
https://www.mol-innov.com/products/IHUPAI1RSMVN500UG |
| Description: |
A double mutation (Q123K and R101A) on the human PAI-1 stable mutant background (K154T, Q319L, M354I and N150H) results in PAI-1 with a greatly extended half life and greatly reduced binding to the important ligand vitronectin.
References
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. Jensen JK, Durand MK, Skeldal S, Dupont DM, Bødker JS, Wind T, Andreasen PA. FEBS Lett. 2004 Jan 2;556(1-3):175-9.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1. Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis. J. Biol. Chem., Apr 2004; 279:17914-20. |
| Recommended Storage: |
SAMPLE |
| Minimum Shelf Life: |
500.50 |
| Source: |
2.5 mg/ml |
| Molecular Weight: |
Proteins |
| Extinction Coefficient: |
43,000 |
| Antigen: |
-70 C |
| Target: |
Frozen liquid |
| Target Molecular Weight: |
PAI-1 |
| Host: |
819 |
| Clonality: |
30 |
| Isotype: |
E. coli |
| Clone: |
s |
| Applications: |
Dry ice |
| Cross-reactivity: |
3 years from delivery |
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| Sample Characteristics |
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| Lot Number: |
CPAI-QR-IHUPAI1RSMVN1MG |
| Aliquot: |
1 x Human PAI-1 Recombinant Stable Mutant Vitronectin Binding Negative 1 mg |
| Concentration: |
715 |
| Volume: |
1170 |
| Titer: |
0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6 |
| Buffer: |
SAMPLE |
| Form: |
0.5 mg |
| Preservative: |
0.2 ml |
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| Optimal experimental conditions and working dilutions must be determined by the end user. Sample concentration and volume are for example purposes only and do not necessarily represent the product that will be received. Please contact us for a current lot-specific product datasheet. |
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| For in vitro laboratory use only |
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Molecular Innovations, Inc. - 46430 Peary Court, Novi, MI 48377, USA
Tel: (888) 557-5055 - Fax: (248) 896-0148 - info@mol-innov.com |