VEGFB Knockout Mice
This Vascular Endothelial Growth Factor B (VEGFB) knockout mouse model was created by targeted disruption of VEGFB using programed nuclease. VEGFB is a member of the VEGF/Platelet-Derived Growth Factor (PDGF) family which regulates the formation of blood vessels and is involved in endothelial cell physiology. VEGFB is alternately spliced into two distinct isoforms, VEGF-B167 and VEGF-B186. VEGFB is a ligand for Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1) and Neuropilin-1 (NRP-1). Mutations are confirmed by PCR genotyping and Sanger sequencing.This VEGFB KO mouse model will be useful for diabetes and metabolic homeostasis research.
Strain Background: C57BL6/SJL
Protein: Vascular Endothelial Growth Factor B
Synonyms: VEGF-B, VEGF-Related Factor, VRF, VEGFL
Genomic Target: Exon 3
Mutation: Large deletions
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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