Recombinant Rat Coagulation Factor XIIa
Rat Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system of blood coagulation. Recombinant insect cell derived rat Factor α-XIIa is manufactured by activation of recombinant rat Factor XII with human kallikrein followed by removal of the activator. >95percent activation is observed on SDS-PAGE. The protein purity is determined by SDS-PAGE and activity is determined via complementation in an APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for more details.