Non-enzymatic non-cleavable Mouse tPA


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Product Description

Non-enzymatic non-cleavable Mouse tPA

Mouse tPA with a double mutation that is permanently single chain and lacks catalytic activity. The non-catalytic mutation site is S481A on the mature protein and S510A on the complete mRNA sequence (UniProtKB: locus TPA_MOUSE, accession P11214). The non-cleavable mutation site is 279E on the mature protein and R308E on the complete mRNA sequence (UniProtKB: locus TPA_MOUSE, accession P11214). Recombinantly produced in insect cells.

Gene ID: 18791
Swiss-Prot/UniProt ID: P11214

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1. Brifault C, Gilder AS, Laudati E, Banki M, Gonias SL. Shedding of membrane-associated LDL receptor-related protein-1 from microglia amplifies and sustains neuroinflammation. J Biol Chem. 2017;292(45):18699-18712. Link to article

2. Mantuano E, Azmoon P, Brifault C, et al. Tissue-type plasminogen activator regulates macrophage activation and innate immunity. Blood. 2017;130(11):1364-1374. Link to article