Kininogen, Single Chain HMW, Human Plasma


SKU: HK-HMW Categories: ,

Product Description

Kininogen, Single Chain HMW, Human Plasma

High Molecular Weight kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a nonenzymatic cofactor of the contact activation system of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogen links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor alpha-Xlla. Kininogen also forms a complex with Factor XI and accelerates its activation to XIa by alpha-Xlla. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease. >95percent pure by SDS-PAGE and >95percent single chain. Prepared from plasma found negative by FDA accepted
methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

Gene ID: 3827
Swiss-Prot/UniProt ID: P01042

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1. Schmaier AH. Alzheimer’s Disease is In-Part a Thrombo-Hemorrhagic Disorder. J Thromb Haemost. 2016;

2. Kromann-hansen T, Oldenburg E, Yung KW, et al. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior. J Biol Chem. 2016;291(29):15156-68. Link to article

3. Wang Q, Da’dara AA, Skelly PJ. The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin. Parasit Vectors. 2018;11(1):182. Link to article

4. Yamamoto-Imoto, H. A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer’s pathology and cognitive impairment. Link to article