Kininogen, Single Chain HMW, Human Plasma

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SKU: HK-HMW Categories: ,

Product Description

Kininogen, Single Chain HMW, Human Plasma

HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a nonenzymatic cofactor of the contact activation system of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogen links prekallikrein to a negatively charged surface thereby allowing activation to kallikrein by surface bound Factor alpha-Xlla. Kininogen also forms a complex with Factor XI and accelerates its activation to XIa by alpha-Xlla. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease. >95percent pure by SDS-PAGE and >95percent single chain. Prepared from plasma found negative by FDA accepted
methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

Gene ID: 3827
Swiss-Prot/UniProt ID: P01042

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1. Schmaier AH. Alzheimer’s Disease is In-Part a Thrombo-Hemorrhagic Disorder. J Thromb Haemost. 2016;

2. Kromann-hansen T, Oldenburg E, Yung KW, et al. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior. J Biol Chem. 2016;291(29):15156-68. Link to article