Inhibitory monoclonal antibody to human and rabbit PAI-1. It binds to a conformational epitope on PAI-1 converting it into the latent form. Currently being studied as a potential therapeutic agent in animal studies. Purified by immobilized Protein A. IgG1k class.
Gene ID: 5054
Swiss-Prot/UniProt ID: P05121
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1. Li SH, Gorlatova NV, Lawrence DA et-al. Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands. J. Biol. Chem. 2008;283 (26): 18147-57. doi:10.1074/jbc.M709455200 – Free text at pubmed – Pubmed citation