Inhibitory mouse monoclonal to human PAI-1 clone 33H1F7

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Inhibitory mouse monoclonal to human PAI-1 clone 33H1F7

Inhibitory monoclonal antibody to human and mouse PAI-1. It binds to an epitope localized to the F-Helix of PAI-1. The PAI-1/mab complex becomes a substrate rather than an inhibitor of its target proteinases tPA and urokinase. Currently being studied as a potential therapeutic agent in animal models. Purified by immobilized Protein A. IgG1 class.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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1. Huang WT, Akhter H, Jiang C, et al. Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Exp Gerontol. 2015;61:62-75. Link to article