Human tissue plasminogen activator, >95% two chain

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Product Description

Human tissue plasminogen activator, >95% two chain

Activated from single-chain form with immobilized plasmin. 100percent complex formation with human PAI-1.

Gene ID: 5327
Swiss-Prot/UniProt ID: P00750

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1. Fjellström O, Deinum J, Sjögren T et-al. Characterization of a small molecule inhibitor of plasminogen activator inhibitor type 1 that accelerates the transition into the latent conformation. J. Biol. Chem. 2013;288 (2): 873-85. doi:10.1074/jbc.M112.371732Free text at pubmedPubmed citation

2. Shahrour, Khaled, Rick Keck, and Jerzy Jankun. ‘Application Of Long-Acting VLHL PAI-1 During Sutureless Partial Nephrectomy In Mice Reduces Bleeding’. BioMed Research International 2015 (2015): 1-7. Web. 5 June 2015. Link to article

3. Kindell, Daniel, Rick Keck, and Jerzy Jankun. ‘Comparison Between The Clot-Protecting Activity Of A Mutant Plasminogen Activator Inhibitor-1 With A Very Long Half-Life And 6-Aminocaproic Acid’. Experimental and Therapeutic Medicine (2015): n. pag. Web. 5 June 2015. Link to article

4. Qureshi T, Peterson CB. Single fluorescence probes along the reactive center loop reveal site-specific changes during the latency transition of PAI-1. Protein Sci. 2016;25(2):487-98.

5. Qureshi T, Goswami S, Mcclintock CS, Ramsey MT, Peterson CB. Distinct encounter complexes of PAI-1 with plasminogen activators and vitronectin revealed by changes in the conformation and dynamics of the reactive center loop. Protein Sci. 2016;25(2):499-510.

6. Lee JA, Characterisation of SerpinB2 as a stress response modulator. University of Wollongong Thesis Collection. 2015

7. Bucci JC, Mcclintock CS, Chu Y, et al. Resolving distinct molecular origins for copper effects on PAI-1. J Biol Inorg Chem. 2017;22(7):1123-1135. Link to article

8. Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE. PAI-1 is a critical regulator of FGF23 homeostasis. Sci Adv. 2017;3(9):e1603259. Link to article