Human RAP

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Product Description

Human RAP

Receptor Associated Protein (RAP) is an ubiquitously expressed 39 kDa chaperone for low density lipoprotein receptor-related protein (LRP) and facilitates its proper folding and localization by preventing the binding of ligands. Human RAP is produced recombinantly in E. Coli. Suitable to block receptor function in uptake assays. Contains endotoxin which might trigger signaling events.

Gene ID: 4043
Swiss-Prot/UniProt ID: P30533

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1. Iafrati MD, Vitseva O, Tanriverdi K et-al. Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am. J. Physiol. Heart Circ. Physiol. 2005;288 (4): H1627-32. doi:10.1152/ajpheart.00819.2004Pubmed citation

2. Polavarapu R, Gongora MC, Yi H et-al. Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood. 2007;109 (8): 3270-8. doi:10.1182/blood-2006-08-043125Free text at pubmedPubmed citation

3. Dasgupta S, Navarrete AM, André S et-al. Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 2008;93 (1): 83-9. doi:10.3324/haematol.11535Pubmed citation

4. Sashindranath M, Sales E, Daglas M et-al. The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain. 2012;135 (Pt): 3251-64. doi:10.1093/brain/aws178Free text at pubmedPubmed citation

5. Byun K, Gil SY, Namkoong C et-al. Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis. EMBO Rep. 2014;doi:10.15252/embr.201338317Pubmed citation

6. Sen, A., T. J. Nelson, and D. L. Alkon. ‘Apoe4 And A  Oligomers Reduce BDNF Expression Via HDAC Nuclear Translocation’. Journal of Neuroscience 35.19 (2015): 7538-7551. Web. 5 June 2015. Link to article

7. Lee JA, Characterisation of SerpinB2 as a stress response modulator. University of Wollongong Thesis Collection. 2015