Human PAI-1 (vitronectin reduced binding mutant)


SKU: HPAI-Q123K Categories: ,

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Human PAI-1 (vitronectin reduced binding mutant)

A single mutation results in ten-fold loss of binding of the PAI-1 mutant to the important ligand vitronectin. All other aspects of PAI-1 biological activity such as anti-protease activity remain unaffected.
Construction of a plasminogen activator inhibitor-1 variant without measurable affinity to vitronectin but otherwise normal. Jensen JK, Durand MK, Skeldal S, Dupont DM, Bødker JS, Wind T, Andreasen PA. FEBS Lett. 2004 Jan 2;556(1-3):175-9.
Conservation of Critical Functional Domains in Murine Plasminogen Activator Inhibitor-1. Zhi Xu, Rashna D. Balsara, Natalia V. Gorlatova, Daniel A. Lawrence, Francis J. Castellino, and Victoria A. Ploplis. J. Biol. Chem., Apr 2004; 279:17914-20.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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1. Arndt PG, Young SK, Worthen GS. Regulation of lipopolysaccharide-induced lung inflammation by plasminogen activator Inhibitor-1 through a JNK-mediated pathway. J. Immunol. 2005;175 (6): 4049-59. J. Immunol. (link)Pubmed citation

2. Vial D, Mckeown-longo PJ. PAI1 stimulates assembly of the fibronectin matrix in osteosarcoma cells through crosstalk between the alphavbeta5 and alpha5beta1 integrins. J. Cell. Sci. 2008;121 (Pt 10): 1661-70. doi:10.1242/jcs.020149Free text at pubmedPubmed citation

3. Adair JE, Stober V, Sobhany M et-al. Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J. Biol. Chem. 2009;284 (25): 16922-30. doi:10.1074/jbc.M808560200Free text at pubmedPubmed citation

4. Florova G, Karandashova S, Declerck PJ et-al. Remarkable stabilization of plasminogen activator inhibitor 1 in a “molecular sandwich” complex. Biochemistry. 2013;52 (27): 4697-709. doi:10.1021/bi400470sFree text at pubmedPubmed citation