Human PAI-1 (substrate form – P12 Glutamate mutant)

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Product Description

Human PAI-1 (substrate form – P12 Glutamate mutant)

From the laboratory of Professor Paul Declerck – Leuven BELGIUM. A single substitution at position P12 in the reactive center loop produces a PAI-1 that becomes a substrate for proteinases rather than an inhibitor. Reactive center loop insertion follows protease cleavage and the PAI-1 loses vitronectin binding properties. This molecule is useful for mechanistic studies.
References
1. Aertgeerts, K. et al. (1995) Proteins 23:118-121.
2. Aertgeerts, K. et al. (1995) Nat. Struct. Biol. 2:891-897.
3. Xue, Y. et al. (1998) Structure 6:627-636.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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