Human PAI -1 Elastase specific mutant

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Human PAI -1 Elastase specific mutant

A single mutation at the P1 position of PAI-1 alters the target specificity of PAI-1 from the plasminogen activators tPA and uPA to elastase. PAI-1 is normally a substrate for pancreatic and neutrophil elastase becoming cleaved at the P3 position. This mutant contains a P1 Alanine in place of the wild type Arginine residue resulting in an inhibitor of elastase as potent as alpha-1PI (antitrypsin).

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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