Human PAI -1 Cathepsin G specific mutant

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Human PAI -1 Cathepsin G specific mutant

A single mutation at the P1 position of PAI-1 alters the target specificity of PAI-1 from the plasminogen activators tPA and uPA to Cathepsin G. This mutant contains a P1 Phenylalanine in place of the wild type Arginine residue (R346F) resulting in an inhibitor with the specificity of antichymotrypsin.

Gene ID: 5054
Swiss-Prot/UniProt ID: P05121

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