Human Lys plasmin

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Product Description

Human Lys plasmin

Prepared from Glu plasminogen by activation with immobilized human uPA. 100 percent functionally active plasmin is purified from the activation reaction by immobilized SBTI. Plasmin will undergo rapid auto proteolysis in the absence of benzamidine and should be used quickly once thawed. Aliquot to avoid freeze-thaw cycles.

Gene ID: 5340
Swiss-Prot/UniProt ID: P00747

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1. Wu F, Wu J, Nicholson AD et-al. Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain. J. Neurosci. 2012;32 (29): 9848-58. doi:10.1523/JNEUROSCI.1241-12.2012Free text at pubmedPubmed citation

2. De lorenzi V, Sarra ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin. EMBO Rep. 2016. Link to article

3. Kromann-hansen T, Oldenburg E, Yung KW, et al. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior. J Biol Chem. 2016;291(29):15156-68. Link to article

4. Middendorp SJ, Wilbs J, Quarroz C, Calzavarini S, Angelillo-scherrer A, Heinis C. Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity. J Med Chem. 2017;60(3):1151-1158. Link to article

5. Boren J, Shryock G, Fergis A, et al. Inhibition of Glycogen Synthase Kinase 3β Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice. Am J Pathol. 2017;187(11):2461-2472. Link to article