Human LMW urokinase

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Product Description

Human LMW urokinase

The low molecular weight form of uPA is purified from auto-catalytic digestion of recombinant human urokinase produced in insect cells. LMW uPA contains the proteinase domain and is separated from the amino terminal fragment by cleavage at the Lys135-Lys136 bond. For plasminogen activation and receptor binding studies.

Gene ID: 5328
Swiss-Prot/UniProt ID: P00749

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1. Lund IK, Jögi A, Rønø B et-al. Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo. J. Biol. Chem. 2008;283 (47): 32506-15. doi:10.1074/jbc.M801924200Pubmed citation

2. De lorenzi V, Sarra ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin. EMBO Rep. 2016. Link to article

3. Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE. PAI-1 is a critical regulator of FGF23 homeostasis. Sci Adv. 2017;3(9):e1603259. Link to article