Human HMW Urokinase

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Product Description

Human HMW Urokinase

Prepared from human urine as the two-chain form. For plasminogen activation and receptor binding studies.

Gene ID: 5328
Swiss-Prot/UniProt ID: P00749

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1. Gardell SJ, Krueger JA, Antrilli TA et-al. Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. Mol. Pharmacol. 2007;72 (4): 897-906. doi:10.1124/mol.107.037010Pubmed citation

2. Szabo R, Hobson JP, List K et-al. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J. Biol. Chem. 2008;283 (43): 29495-504. doi:10.1074/jbc.M801970200Free text at pubmedPubmed citation

3. Lund IK, Jögi A, Rønø B et-al. Antibody-mediated targeting of the urokinase-type plasminogen activator proteolytic function neutralizes fibrinolysis in vivo. J. Biol. Chem. 2008;283 (47): 32506-15. doi:10.1074/jbc.M801924200Pubmed citation

4. Courey AJ, Horowitz JC, Kim KK et-al. The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice. Blood. 2011;118 (8): 2313-21. doi:10.1182/blood-2010-12-324574Free text at pubmedPubmed citation

5. Larusch GA, Merkulova A, Mahdi F et-al. Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2. Am. J. Physiol. Heart Circ. Physiol. 2013;305 (3): H305-20. doi:10.1152/ajpheart.00110.2013Free text at pubmedPubmed citation

6. Jablonka W, Kotsyfakis M, Mizurini DM, et al. Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin. PLoS ONE. 2015;10(8):e0133991. Link to article

7. De lorenzi V, Sarra ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin. EMBO Rep. 2016. Link to article

8. Kromann-hansen T, Oldenburg E, Yung KW, et al. A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior. J Biol Chem. 2016;291(29):15156-68. Link to article

9. Middendorp SJ, Wilbs J, Quarroz C, Calzavarini S, Angelillo-scherrer A, Heinis C. Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity. J Med Chem. 2017;60(3):1151-1158. Link to article