Human Factor Xa
Factor Xa is prepared by activating purified Factor X with the Factor X activator isolated from Russell’s viper venom. Cleavage occurs at the Arg51-Ile52 bond and releases an activation peptide. Factor Xa is purified from the activation mixture by chromatography over immobilized benzamidine. Purity is determined by SDS-PAGE analysis and activity is measured in a Factor Xa clotting assay and/or chromogenic substrate assay.
Gene ID: 2159
Swiss-Prot/UniProt ID: P00742
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1. Yang J, Su G, Ren Y, Chen Y. Synthesis of 3,4-diaminobenzoyl derivatives as factor Xa inhibitors. Eur J Med Chem. 2015;101:41-51. Link to article
2. Sorensen AB, Madsen JJ, Svensson LA, et al. Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J Biol Chem. 2016;291(9):4671-83.