Human coagulation Factor beta-XIIa


SKU: HFXIIAB Categories: ,

Product Description

Human coagulation Factor beta-XIIa

Human Factor beta-XIIa is generated in vivo by kallikrein cleavage of Factor alpha-XIIa and contains the catalytic light chain and the C-terminal peptide of the heavy chain of Factor alpha-XIIa. Human Factor beta-XIIa is activated from homogeneous Human Factor XII by an autoactivation process with Dextran Sulfate followed by repurification to isolate Factor alpha-XIIa (Cat # HFXIIA) and Factor beta-XIIa. Complete activation is observed on SDS-PAGE. Factor XIIa is >95percent pure by SDS-PAGE and activity is determined via clotting assay. Prepared from plasma found negative by FDA accepted methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

Gene ID: 2161
Swiss-Prot/UniProt ID: P00748

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1. Baeriswyl, Vanessa et al. ‘A Synthetic Factor Xiia Inhibitor Blocks Selectively Intrinsic Coagulation Initiation’. ACS Chem. Biol. (2015): 150519135510007. Web. 5 June 2015. link to article

2. Rentero rebollo I, Sabisz M, Baeriswyl V, Heinis C. Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides. Nucleic Acids Res. 2014;42(22):e169. link to article

3. Middendorp SJ, Wilbs J, Quarroz C, Calzavarini S, Angelillo-scherrer A, Heinis C. Peptide Macrocycle Inhibitor of Coagulation Factor XII with Subnanomolar Affinity and High Target Selectivity. J Med Chem. 2017;60(3):1151-1158. Link to article

4. Dementiev A, Silva A, Yee C, et al. Structures of human plasma β-factor XIIa cocrystallized with potent inhibitors. Blood Adv. 2018;2(5):549-558. Link to article