Human alpha 2 antiplasmin


SKU: HA2AP Categories: ,

Product Description

Human alpha 2 antiplasmin

Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma at about 70 ug per ml. Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.

Gene ID: 5345
Swiss-Prot/UniProt ID: P08697

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1. Allard S, Leon WC, Pakavathkumar P et-al. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J. Neurosci. 2012;32 (6): 2002-12. doi:10.1523/JNEUROSCI.1144-11.2012Pubmed citation

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3. Valiente M, Obenauf AC, Jin X et-al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014;156 (5): 1002-16. doi:10.1016/j.cell.2014.01.040Pubmed citation

4. De lorenzi V, Sarra ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin. EMBO Rep. 2016. Link to article

5. Dupont DM, Madsen JB, Hartmann RK, et al. Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA. 2010;16(12):2360-9. Link to article

6. Botkjaer KA, Deryugina EI, Dupont DM, et al. Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism. Mol Cancer Res. 2012;10(12):1532-43. Link to article

7. Allard S, Jacobs ML, Do carmo S, Cuello AC. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Neurobiol Aging. 2018;67:10-20. Link to article

8. García-vázquez FA, Soriano-Úbeda C, Laguna-barraza R, et al. Tissue plasminogen activator (tPA) of paternal origin is necessary for the success of invitro but not of invivo fertilisation in the mouse. Reprod Fertil Dev. 2018; Link to article

9. Sugioka K, Kodama-takahshi A, Sato T, et al. Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2018;59(12):5098-5107. Link to article