Human alpha 2 antiplasmin

$450$3,960

Clear
SKU: HA2AP Categories: ,

Product Description

Human alpha 2 antiplasmin

Efficiently inhibits the plasminogen-activator-induced lysis of fibrin clots. Found in plasma at about 70 ug per ml. Alpha-antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. >95percent pure by SDS-PAGE. Add deionized water to original volume, aliquot and freeze unused portion.

Gene ID: 5345
Swiss-Prot/UniProt ID: P08697

View sample datasheet
View sample certificate of analysis
View material safety data sheet
Ask a question about this product

Additional Information

Purity

Source

Molecular Weight

Activity

Extinction Coefficient

Species

Storage

Shipping Conditions

Expiration

Form

Buffer

Sample Size

Sample Concentration

Sample Volume

Gene Name

Gene ID

UniProt ID

1. Allard S, Leon WC, Pakavathkumar P et-al. Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J. Neurosci. 2012;32 (6): 2002-12. doi:10.1523/JNEUROSCI.1144-11.2012Pubmed citation

2. Nolan M, Bouldin SD, Bock PE. Full time course kinetics of the streptokinase-plasminogen activation pathway. J. Biol. Chem. 2013;288 (41): 29482-93. doi:10.1074/jbc.M113.477935Free text at pubmedPubmed citation

3. Valiente M, Obenauf AC, Jin X et-al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 2014;156 (5): 1002-16. doi:10.1016/j.cell.2014.01.040Pubmed citation

4. De lorenzi V, Sarra ferraris GM, Madsen JB, Lupia M, Andreasen PA, Sidenius N. Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin. EMBO Rep. 2016. Link to article

5. Dupont DM, Madsen JB, Hartmann RK, et al. Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA. 2010;16(12):2360-9. Link to article

6. Botkjaer KA, Deryugina EI, Dupont DM, et al. Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism. Mol Cancer Res. 2012;10(12):1532-43. Link to article

7. Allard S, Jacobs ML, Do carmo S, Cuello AC. Compromise of cortical proNGF maturation causes selective retrograde atrophy in cholinergic nucleus basalis neurons. Neurobiol Aging. 2018;67:10-20. Link to article