Hemophilia B Mice
This hemophilia B mouse model was created by targeted disruption of Factor IX (F9) using programed nuclease. Mutations are confirmed by PCR genotyping, Sanger sequencing, and RT-PCR. Male hemizygotes display severe hemophilia B phenotype with prolonged blood clotting time and exhibit death after tail clipping without cauterizing. This hemophilia B mouse model will be useful for studying gene therapy methods.
Strain Background: C57BL6/SJL
Protein: Coagulation Factor IX
Synonyms: FIX, Christmas Factor
Genomic Target: Exon 1
Mutation: 2 base pair deletion
Phenotype: Prolonged clotting time (aPTT), tail clipping induced mortality
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.
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