Factor XI Knockout Mice
This Factor XI (F11) knockout mouse model was created by targeted disruption of F11 using programed nuclease. Mutations are confirmed by PCR genotyping and Sanger sequencing. The complete absence of FXI protein in the plasma of homozygous mice is confirmed by Western Blot. This mouse model will be useful for cardiovascular and hemostasis research.
Strain Background: C57BL/6
Protein: Coagulation Factor XI
Synonyms: FXI, Plasma Thromboplastin Antecedent
Genomic Target: Exon 5
Mutation: 101 base pair deletion
Our mutant mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A. Cryopreserved.
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