PAI-1 Knockin Mice

PAI-1 Knockin Mice

This PAI-1 KI mouse model was created by targeted substitution of critical amino acids using programed nuclease. A single amino acid point mutation results in PAI-1 with reduced binding to the serum protein vitronectin. These vitronectin binding deficient mice are in breeding now and homozygous mice will be available soon.

DETAILS
Strain background: C57B6SJL
Chromosome: 5
Gene: Serpine1
Targeted Exon: Exon 2
Mutation: Arg124>Ala

We also provide custom Knockout Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report.