PAI-1 Knockin Mice
This PAI-1 KI mouse model was created by targeted substitution of critical amino acids using programed nuclease. A single amino acid point mutation results in PAI-1 with reduced binding to the serum protein vitronectin. These vitronectin binding deficient mice are in breeding now and homozygous mice will be available soon.
Strain background: C57B6SJL
Targeted Exon: Exon 2
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Click here to read our recent research model report.