Hemophilia B Mouse Model

Molecular Innovations would like to introduce our hemophilia B mouse model. This model was created by targeted disruption of Factor IX using programed nuclease. Mutations are confirmed by PCR genotyping, Sanger sequencing, and RT-PCR. Male hemizygotes display severe hemophilia B phenotype with prolonged blood clotting time and exhibit death after tail clipping without cauterizing. This hemophilia B mouse model will be useful for studying gene therapy methods.

Our hemophilia B mice are from an ongoing colony made in-house at our state of the art facility in the U.S.A and available immediately. No waiting for cryo recovery or costly breeding.

DETAILS

Strain background: C57BL/6J
Chromosome: X
Gene: FIX
Targeted Exon: Exon 1
Mutation: 2 bp deletion on Exon 1 creating a premature stop codon (null/complete knockout)
Phenotype:  bleeding disorder (prolonged clotting time (aPTT), tail clipping induced mortality)

Click here to order strain C57BL/6J Hemophilia B mice.

We also provide custom Knockout Mouse Model projects and offer FREE consulting services from our expert scientific staff along with very competitive pricing. Click here to inquire.

Click here to read our recent research model report.